|Venue: Cardiff Arms Park Date: Saturday, 23 April Kick-off:17:15 BST
|Coverage:Live on S4C. Highlights and match report on BBC Sport's website and app. Highlights on Scrum V from 18:00 BST Sunday, BBC Two Wales and online
Alun Wyn Jones will be the first Ospreys player to make 250 Ospreys games when they take on Cardiff on Saturday.
Jones, 36, will be playing for the first time since March's Six Nations defeat by Italy. He will line up with Adam Beard in row 2.
Cardiff's first Arms Park league match with Ospreys is led by Josh Navidi
After last weekend's loss at Saracens Rey Lee Lo and Theo Cabango were among the people recalled by Cardiff.
Samoa international Lee-Lo begins in the middle, while Cabango replaces Aled Summerhill who is injured on the wing.
Another injury absentee is Corey Domachowski Dmitri Ahip and Rhys Carre were both recalled in the front row. James Ratti, who is fit again, was number eight.
“We're all excited about Saturday and look forward to getting back infront of our home fans,” said Dai Young, Cardiff director for rugby.
“The boys want something to be proud off and they go into the match on the backs of a much better performance against Saracens.
“It's clear that the Ospreys will pose a challenge. They are a top team with a powerful pack and some very skilled backs. They are coming to win.
“But we cannot only focus on ourselves and do all we can to achieve the desired level of performance.”
Rhys Webb is the Scrum-half of Ospreys. Gareth Anscombe is fly-half, and Keelan Giles starts on the wing.
Jones' return means six Welsh internationals are in the Ospreys team as the Swansea-based Ospreys team visit Cardiff's place. They have played them many times at Principality Stadium on Judgement Days, since 2013.
Toby Booth, Ospreys head coach, stated that “we are still in with the chance for the Welsh Shield”
“Derbies are about doing what you want to do and the competition for Saracens probably helped them.
“We are aware they are at their home and will want to bounce back. They will be looking for a win and they have a positive performance against Saracens to help them prepare.
“It will be an arm wrestle and that is how derbies usually are. It's about how well you handle pressure, keep your nerve and deliver the game you want to deliver.
Cardiff:Hallam Amos, Owen Lane, Max Llewellyn and Theo Cabango; Rhys Priestland; Tomos Williams, Rhys Carre; Rhys Carre; Liam Belcher; Dmitri Arkhip, Seb Davies; Rory Thornton; Shane Lewis-Hughes; Josh Navidi (capt), James Ratti.
Replacements: Kristian Dacey, Brad Thyer, Dillon Lewis, Matthew Screech, James Botham, Lloyd Williams, Jarrod Evans, Matthew Morgan
Ospreys:Max Nagy, Alex Cuthbert; Owen Watkin; Owen Watkin; Keelan Giles, Gareth Anscombe; Gareth Thomas (capt); Gareth Thomas; Dewi Lake; Tomas Francis. Adam Beard, Alun Wyn Jones, Will Griffiths, Jac Morgan, Morgan Morris.
Replacements: Sam Parry. Nicky Smith, Tom Botha and Rhys Davies. Ethan Roots. Reuben Morgan-Williams.
Referee: Gianluca Gnecchi (FIR)
Assistant referees:Adam Jones, Jason Bessant
TMO:Sean Brickell (WRU).