Elliot Daly will miss all of England’s Six Nations marketing campaign after the full-back suffered a hamstring damage enjoying for Saracens.
The 30-year-old, who has gained 57 worldwide caps, is anticipated to be out of motion for round 12 weeks.
He was pressured off throughout the second half of Saracens’ European Champions Cup defeat at Edinburgh on Sunday.
Former Wasps man Daly, who may play at centre and on the wing, made his England debut in 2016.
On Tuesday Daly had withdrawn from the England training squad which is getting ready for the Six Nations opener towards Scotland on 4 February.
New head coach Steve Borthwick has already needed to take care of a lot of accidents as he prepares for his first match in cost, having taken over from Eddie Jones in December.
Ahead Courtney Lawes and hooker George McGuigan pulled out of the squad on Monday with calf and knee accidents respectively, whereas Exeter ahead Luke Cowan-Dickie will miss at the least the beginning of the event with an ankle downside.
After their opener towards Scotland at Twickenham, England host Italy on 12 February.
A visit to Wales follows on 25 February earlier than a house sport towards defending champions France on 11 March precedes their last sport towards Eire on 18 March in Dublin.
A 12-week absence may see Daly again in motion for Saracens within the Premiership leaders’ last sport of the common marketing campaign at Bathtub on the primary weekend in Could.
This season’s Premiership last is on Saturday, 27 Could at Twickenham, with the European Champions Cup last seven days beforehand in Dublin.