|Venue: Matmut Stadium Date:Saturday, 14 Mai Kick-off:12:00 BST Coverage: Live scores and updates on BBC Sport.|
Two changes are made by Lee Blackett, the Wasps' head coach for the trip to Lyon. The Wasps hope to win in France and reach their 15th European final.
Jacob Umaga makes his debut at fullback after the victory over Worcester, 41-12 Premiership on 23 April.
Malakai Fekitoa makes a comeback at the centre, and Sam Spink is on the bench.
Blackett stated, “These moments are what you do all for, in order to reach the knockout stages competitions.”
“When you lose the Champions Cup you have to do it the hard way. There are a lot away games.
Unchanged Lyon was the dominant team in their group. They won all four matches and then beat Worcester and Edinburgh in knockouts to reach their first European semi final.
They are a team of form, a big collision group. They looked comfortable winning the game against Glasgow because of the way they came back.
“They score tries from broken field, and if it comes down to individual moments they've got people that can harm you, that's for sure,” Blackett told BBC Coventry & Warwickshire.
Joe Launchbury is again the captain of the Wasps. They won the Challenge Cup 2003 against Bath, but their last European victory was in the Champions Cup 2007.
Jimmy Gopperth's seven-year club career would be completed with a winning medal. Fekitoa is in the middle of the team for next season. Fekitoa scored one last week. .
Lyon: Arnold; Tuisova, Barassi, Ngatai, Niniashvili; Berdeu, Couilloud; S Taofifenua, Marchand, Bamba, Kpoku, R Taofifenua, Cretin, Saginadze, Sobela (capt).
Replacements: Charcosset, Rey, Kodela, Mayanavanua, Goujon, Doussain, Lambey, Mignot.
Wasps:Umaga; Hougaard; Fekitoa; Gopperth; Bassett, Atkinson; Atkinson; Robson West, Oghre Alo (capt), Launchbury (capt), Stooke Shields J Willis Barbeary
Replacements: Frost, Harris, Millar-Mills, Gaskell, T Willis, Porter, Spink, Kibirige.
Referee:Frank Murphy (Ireland).