|Venue: Twickenham Date:Saturday, 21 Mai Kick-off:12:00 BST Coverage: Check out the BBC Sport website for updates and live scores.|
With a victory against Gloucester at Twickenham, Harlequins will be able to secure their play-off semifinal position in Premiership.
Quins make one adjustment to the side that was lost Northampton, last month. Prop Will Collier was recalled.
With victory, Gloucester can increase their top-four hopes and make four team changes This month, earlier.
Giorgi Kaveseladze opens the centre to visitors.
Santiago Socino, a hooker, and Kirill Goutsev are in the front row. Ruan Ahlermann is at the flanker.
In their five previous matches at England's national stadium, Harlequins have never lost.
In the final league match of the season, Gloucester hosts Saracens. Harlequins will travel to Exeter.
Tabai Matson, Harlequins' head coach, told the club website:“I believe that our game against Gloucester earlier in the season was probably one our grittiest.
You have to be at your best when playing in such a team. Their play style is very pragmatic and they have a great scrum.
“Their maul has the best record in the league. On Saturday, it will be even more like that. We'll see a variety of styles, so we need to be careful not to let them in too early.
George Skivington, Gloucester's head coach, told the club website:They are a great team. They are the English champions. They're blessed with some top players. It seems that they truly enjoy what they do.
There are many threats to the team and I don’t see them as having any particular weaknesses. They seem to have a lot of connections and they seem to really enjoy what they're doing. This is a very important trait for anyone in this field. I admire them a lot and we've seen a lot so we are familiar with the challenges they face.
“There are quality players who can do things that you can’t. You must be prepared for everything.
Harlequins:Jones; Lynagh; Marchant; Esterhuizen; Murley; Smith; Smith, Care. Kerrod, Walker; Collier. Symons; Tizard. Lewies (capt.), Lawday, Dombrandt
Replacements: Musk, Marler, Louw, Jurevicius, Evans, Gjaltema, Allan, David
Gloucester:Carreras; ReesZammit; Harris, Kveseladze; Thorley; Hastings and Chapman; Rapava–Ruskin; Socino, Gotovtsev, Clarke; Alemanno, Ackermann; Ludlow (capt.Morgan
Replacements: Singleton, Elrington, Balmain, Davidson, Reid, Meehan, Twelvetrees, Seabrook